Joseph Longo Selected Research

Neoplasms (Cancer)

3/2024	Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides.
12/2023	Ketolysis drives CD8+ T cell effector function through effects on histone acetylation.
9/2023	Acod1 Expression in Cancer Cells Promotes Immune Evasion through the Generation of Inhibitory Peptides.
10/2022	Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins.
1/2022	Statins and prostate cancer-hype or hope? The biological perspective.
11/2021	Quantitative Prostate MRI Analysis Following Fluvastatin Therapy for Localized Prostate Cancer - A Pilot Study.
1/2021	The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma.
1/2021	Mevalonate Pathway Inhibition Slows Breast Cancer Metastasis via Reduced N-glycosylation Abundance and Branching.
12/2020	A pilot window-of-opportunity study of preoperative fluvastatin in localized prostate cancer.
11/2020	Statins as Anticancer Agents in the Era of Precision Medicine.

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Joseph Longo Research Topics

Disease

17	Neoplasms (Cancer) 03/2024 - 12/2015
4	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 01/2019
3	Breast Neoplasms (Breast Cancer) 10/2022 - 01/2019
2	Multiple Myeloma 01/2021 - 10/2020
1	Bacterial Infections (Bacterial Infection) 12/2023
1	Listeriosis (Listeria Infection) 01/2022
1	Neoplasm Metastasis (Metastasis) 01/2021
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2020
1	Hematologic Neoplasms (Hematological Malignancy) 10/2020
1	Hypoxia (Hypoxemia) 12/2015
1	Carcinogenesis 09/2015
1	Polyps 09/2015
1	Colorectal Neoplasms (Colorectal Cancer) 09/2015
1	Intestinal Neoplasms (Intestinal Cancer) 09/2015
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2003

Drug/Important Bio-Agent (IBA)

9	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2022 - 11/2016
6	Mevalonic Acid (Mevalonate)IBA 01/2021 - 11/2016
5	Fluvastatin FDA Link 11/2021 - 01/2018
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2015
2	aconitate decarboxylaseIBA 03/2024 - 09/2023
2	Peptides (Polypeptides)IBA 03/2024 - 09/2023
2	itaconic acidIBA 03/2024 - 09/2023
2	Dipyridamole (Persantine)FDA LinkGeneric 10/2022 - 10/2020
2	CholesterolIBA 01/2022 - 01/2019
2	Caspase 3 (Caspase-3)IBA 11/2021 - 12/2020
2	Oncogene Proteins (Oncogene Protein)IBA 01/2019 - 01/2018
2	Transcription Factors (Transcription Factor)IBA 12/2015 - 09/2015
1	CytokinesIBA 12/2023
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	Bortezomib (Velcade)FDA Link 01/2021
1	Polysaccharides (Glycans)IBA 01/2021
1	N-AcetylglucosaminyltransferasesIBA 01/2021
1	Adenosine Monophosphate (AMP)IBA 10/2020
1	Cilostazol (Pletal)FDA LinkGeneric 10/2020
1	Phosphodiesterase InhibitorsIBA 10/2020
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 10/2020
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 10/2020
1	Cyclic AMP (AMP, Cyclic)IBA 10/2020
1	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 01/2019
1	EnzymesIBA 01/2019
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2019
1	SterolsIBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2018
1	Zinc Finger E-box-Binding Homeobox 1IBA 01/2018
1	geranylgeranyl pyrophosphate (geranylgeranyl diphosphate)IBA 01/2018
1	farnesyl pyrophosphate (farnesyl diphosphate)IBA 01/2018
1	Sorafenib (BAY 43-9006)FDA Link 01/2017
1	Therapeutic UsesIBA 11/2016
1	Oxygen (Dioxygen)IBA 12/2015
1	CateninsIBA 09/2015
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 04/2003
1	oxidized low density lipoproteinIBA 04/2003
1	HomocysteineIBA 04/2003

Therapy/Procedure

6	Therapeutics 03/2024 - 01/2018
1	Prostatectomy (Retropubic Prostatectomy) 11/2021
1	Aftercare (After-Treatment) 12/2020